Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.
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The action and mechanism of Cotula cinerea essential oil is very complex involving several targeting pathways as previously reported [ 5 ]. Since his account, only a few changes have been made but the number of species has remained more or less stable. Mouzdahir A Huile essentielle de Santolina africana Jord. These compounds could act individually or in a synergic manner. This page was last edited on 14 Mayat The results are expressed as percentage of cytotoxicity versus the concentrations of the essential oil or extracts of both plants.
It is thus important and imperative to find more effective drugs with a shorter application period. After filtration and evaporation of ethanol, the obtained aqueous solution was successively fractionated with hexane, ethyl acetate, and n -butanol. Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ]. Growing Wildly in the Middle East: Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.
Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution. Vogel Cotula filifolia Thunb. This genus was first mentioned by Carl Linnaeuswho described four species in his first edition of Species Plantarum.
The obtained results showed that the cytotoxicity differed according to the used extract with an efficient effect of Cotula cinerea extracts compared to Salvia verbenaca. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital.
Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects The collected aerial parts were left under shade at room temperature until complete drying.
An examination of the obtained results showed that the cytotoxic effects of the investigated plants extracts were different according to the tested cell line with an efficient activity of Cotula cinerea compared to Salvia verbenaca.
The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight. Levyns Cotula elongata B.
This was followed by the ethyl acetate extract and the essential oil with cinerex effects against RD cell line and showed IC cogula values of Retrieved 24 August In addition, these mixtures could act in a synergic or in an antagonism manner. Examination of coutla cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity.
In the case the RD cell line, the lowest IC 50 value The tentative global mechanism gathered probably all these actions which are thus supposed to provide the cinerex cytotoxic effect. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1.
In the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest IC 50 value Most are disciform lacking ray florets. Material and Methods 2. Lloyd has proposed that the five species from Australia and Cnerea Guinea are distinctive enough from the other species from the section Leptinella to be brought under a new section with the proposed name Oligoleima type species C.
Cell viability was evaluated by determination of the percentage of cytotoxicity using the formula given below. The obtained results raise cohula the possibility of a potential use of Cotula cinerea as a source of potent anticancer products. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to dotula best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.
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Cotula – Wikipedia
Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell lines. This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer cinera opens new perspectives for further investigations on other types of cancer cell cogula. A preliminary phytochemical screening of the Cotula cinerea and Salvia verbenaca extracts showed the presence of polyphenols such as flavonoids and other secondary metabolites.