Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Causes: Infectious bursal disease virus is a birnavirus. It is highly . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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Clinico-pathological studies on natural and experimental infectious bursal disease in broiler chickens. Molecular epidemiology of infectious bursal disease viruses isolated from Southern China during the years — DNA-mediated vaccination conferring protection against infectious bursal disease in broiler chickens in the presence of maternal antibody. Evaluation of maternal immunity and protection by vaccination of one-day old chicks against challenge with a very virulent virus isolate.

Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens. Pathogenicity of Sspl-positive infectious bursal disease virus and molecular characterization of the hypervariable region.

Articles from Veterinary World are provided here courtesy of Veterinary World. Our understanding of IBDV epidemiology has been much more comprehensive by today. A total monetary loss of over three billion Nigerian currency was reported by Musa et al.

The crystal structure of VP2 indicates that most amino acid aa changes are localized in the exposed projection domain that contains the hypervariable region hVP2. A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chickens.

Infectious bursal disease virus in poultry: current status and future prospects

The host genotype influences infectious bursal disease virus pathogenesis in chickens by modulation of T cells responses and cytokine gene expression. Recombinant Semliki Forest virus vector exhibits potential for avian virus vaccine development. Structure and Molecular Biology. Significance of bursa of Fabricius as target organ in infectious bursal disease of chickens. Table-1 Various farms visited for sample collection for suspected IBD outbreaks.

In addition, Hemalatha et al. Acute infectious bursal disease in poultry: Large-scale manufacture and use of recombinant VP2 vaccine against infectious bursal disease in chickens. It is suggested that the progression of an infection within a host will determine the ability of a pathogen to transmit to new hosts and to maintain itself in the population, therefore, additional understanding of IBDV pathogenesis and its interactions with the innate diseaxe system is still required to provide the basis for improved prophylactic strategies.


This article has been cited by other articles in PMC. Vaccination against very virulent infectious bursal disease virus using recombinant T4 bacteriophage displaying viral protein VP2. IBDV-VP2 subunit vaccines produced in yeast and Escherichia coli expression systems have been licensed for commercial use. An experimental study on early pathogenesis of a very virulent isolate of infectious bursal disease virus, employing immunohistochemistry.

For example, low pathogenic duck adapted avian influenza virus becomes more virulent when serially passaged in IBDV-infected chickens. The association of proventriculitis with IBD found in three out of six studied outbreaks goes gumboo accordance with the previous findings by Pantin-Jackwood and Brown [ 35 ] and Grau-Roma et al. The presence of viral antigen was also appreciated in the bursal interfollicular connective tissue Figure-5 as well as the bursal epithelium which was ooultry reported by Oladele et al.

In contaminated premises, it could persist for months and in water, forage and faeces for weeks. Histopathologically, there was rarefaction of the bursal follicles along with the mixed cellular infiltration in the bursal follicles.

Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. Thus, this hypervariable region of VP2 is the obvious target for the molecular techniques applied for IBDV detection and strain variation studies. The greatest bursal mass is mostly a result of a large population of maturing IgM-bearing B-lymphocytes lymphoblaststhe main target of infection. Collection and processing of samples A total of six poultry farms were visited in and around the areas of Ludhiana and the other districts of Punjab, as shown in Table Open in a separate window.

Vectored IBD vaccines as well as immune complex vaccines have been licensed in recent years to overcome some of the problems related to classical vaccines. They produce a watery diarrhea and may have swollen feces-stained vent.

The cerebrum revealed congestion along with the mild perivascular lymphomononuclear cellular cuffing around the blood vessel.

Sequence comparisons of the variable VP2 region of eight infectious bursal disease virus isolates.

INFECTIOUS BURSAL DISEASE (GUMBORO) – Diseases of Poultry – The Poultry Site

The similar reaction was also seen in the cortical lymphocytes of thymus and in few glandular epithelial cells of Harderian gland depending on the days post-infection. Pathological changes, especially haemorrhages, may also be seen in the skeletal muscle, intestines, kidney and spleen. Infectious bursal disease live vaccines: Adaptation of a mallard H5N2 low pathogenicity influenza virus in chickens with prior history of infection diseaase infectious bursal disease virus.


IBD virus has a lymphocidic effect and the most severe injuries are in the lymph follicles of the bursa of Fabricius. Necropsy examination will usually show changes in the bursa of Fabricius such as swelling, oedema, haemorrhage, the presence of a jelly serosa transudate and eventually, bursal atrophy. Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease.

Village chicken production practices in the amatola basin of the Eastern Cape Province, South Africa. These slides were then washed in phosphate buffer saline for 20 min.

Internationally, IBD is also reported endemic in certain areas [ 11 – 13 ]. Expression and localization of IBD specific viral antigens were noticed mainly intracellular to the rarefied areas of bursal follicle section sin conjunction to inner lining of the cystic cavities of affected follicles. Gross The bursa of Fabricius in the affected birds aged weeks were found showing significant lesions in the birds, which were necropsied in five different farms and showed the atrophic changes.

Javascript is currently disabled in your browser. Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus IBDV delivered by the attenuated Salmonella elicits protective immune responses in chickens.

Acute disease and death is due to the necrotizing effect of these viruses on the host tissues.

Infectious bursal disease

Diagnosis of infectious bursal disease by immunoperoxidase technique. Molecular characteristics of segment B of seven very virulent infectious bursal disease viruses isolated in China. The presence of disase was highest in the fifth outbreak 1.

Sequence and phylogenetic analysis of a Chinese very virulent infectious bursal disease virus.